Characterization of the human, mouse and rat PGC1β (peroxisome- proliferator-activated receptor-γ co-activator 1β) gene in vitro and in vivo
نویسندگان
چکیده
*Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge, U.K., †Cardiovascular and Gastrointestinal Discovery Research Department, AstraZeneca Pharmaceuticals, Macclesfield, U.K., ‡MRC Dunn Human Nutrition Unit, Cambridge, U.K., and §Departments of Exercise, Sport Science and Physiology, East Carolina University, Greenville, NC 27858, U.S.A.
منابع مشابه
Compare the Effect of Eicosapentaenoic Acid and Oxidized Low-Density Lipoprotein on the Expression of CD36 and Peroxisome Proliferator-Activated Receptor Gamma
Background: There is evidence that CD36 promotes foam cell formation through internalizing oxidized LDL (ox-LDL) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. In addition, CD36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of the present study was to evaluate and compare the effect of ...
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Alzheimer’s disease (AD) is undoubtedly one of the serious and growing public health challenges in the world today. There is an unmet need for new and effective preventative and therapeutic treatment approaches for AD, particularly at early stages of the disease. However, the underlying mechanism against Aβ-induced electrophysiological alteration in cultured hippocampal pyramidal neurons is st...
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Peroxisome proliferator-activated receptor alpha (PPAR-α), which belongs to the nuclear receptor family of ligand-activated transcription factors, was first described as gene regulators for metabolic pathways including lipid metabolism, insulin sensitivity, and glucose homeostasis. Were raised. This nuclear receptor is widely expressed in various tissues, providing a wide range of effects to st...
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